What is the endothelium — or why do we age?
«Everyone hopes to live long, but no one wants to be old»
«The health of a person, as well as his age, is determined by the state of his blood vessels»
Endothelium — a single layer of flat cells lining the inner surface of the blood and lymphatic vessels, as well as the cavities of the heart. Until recently, it was believed that the main function of the endothelium is to polish the vessels from the inside. And only at the end of the 20th century, after the Nobel Prize in Medicine was awarded in 1998, it became clear that the main cause of arterial hypertension (popularly known as hypertension) and other cardiovascular diseases is endothelial pathology.
Right now we are beginning to understand how important the role of this body is. Yes, it is an organ, because the total weight of endothelial cells is 1.5-2 kg (like the liver!), and its surface area is equal to the area of a football field. So what are the functions of the endothelium, this huge organ distributed throughout the human body?
There are 4 main functions of the endothelium:
1. Regulation of vascular tone — support for normal blood pressure (BP); vasoconstriction, when it is necessary to restrict blood flow (for example, in the cold to reduce heat loss), or their expansion in an actively working organ (muscle, pancreas during the production of digestive enzymes, liver, brain, etc.), when it is necessary to increase its blood supply.
2. Expansion and restoration of the network of blood vessels. This function of the endothelium ensures tissue growth and healing processes. It is endothelial cells in the entire vascular system of an adult organism that divide, move and create new vessels. For example, in some organ, after inflammation, part of the tissue dies. Phagocytes eat dead cells, and in the affected area, germinating endothelial cells form new capillaries through which stem cells enter the tissue and partially restore the damaged organ. This is how all cells, including nerve cells, are restored. Nerve cells are restored! This is a proven fact.
The problem is not how we get sick. More important is how we recover! It is not the years that age, but the disease!
3. Regulation of blood coagulation. The endothelium prevents the formation of blood clots and activates the process of blood clotting when the vessel is damaged.
4. The endothelium is actively involved in the process of local inflammation — a protective mechanism for survival. If somewhere in the body, something alien sometimes begins to raise its head, then it is the endothelium that begins to pass protective antibodies and leukocytes from the blood through the vessel wall into the tissue in this place.
The endothelium performs these functions by producing and releasing a large number of different biologically active substances. But the main molecule produced by the endothelium is NO — nitric oxide. It was the discovery of the key role of NO in the regulation of vascular tone (in other words, blood pressure) and the state of the vessels in general that was awarded the Nobel Prize in 1998. A properly functioning endothelium continuously produces NO, maintaining normal pressure in the vessels. If the amount of NO decreases as a result of a decrease in the production of endothelial cells or its decomposition by active radicals, the vessels cannot adequately expand and deliver more nutrients and oxygen to actively working organs.
NO is chemically unstable — it only exists for a few seconds. Therefore, NO only works where it is released. And if endothelial functions are disturbed somewhere, then other, healthy, endothelial cells cannot compensate for local endothelial dysfunction. Local insufficiency of blood supply develops — ischemic disease. Specific organ cells die and are replaced by connective tissue. Aging of organs develops, which sooner or later manifests itself as pain in the heart, constipation, dysfunction of the liver, pancreas, retina, etc. These processes proceed slowly, and, often, imperceptibly for the person himself, however, they are sharply accelerated in any illness. The more severe the disease, the more massive the damage to tissues, the more it will have to be restored.
The main task of medicine has always been to save human life. Actually, for the sake of this noble cause, we entered the medical institute and taught us this, and we taught. However, it is equally important to ensure the recovery process after an illness, to provide the body with everything it needs. If you think that antibiotics or antiviral drugs (I mean those that actually work on the virus) cure a person of an infection, then you are mistaken. These drugs stop the progressive reproduction of bacteria and viruses. And the cure, i.e. the destruction of the unviable and the restoration of what was, is carried out by the cells of the immune system, endothelial cells and stem cells!
The better the process is provided with everything necessary, the more complete the restoration will occur — first of all, the blood supply to the affected part of the organ. This is what LongaDNA was created for. It contains L-arginine — a source of NO, vitamins that provide metabolism inside a dividing cell, DNA, which is necessary for the full process of cell division.
What is L-arginine and DNA and how do they work:
L-arginine is an amino acid, the main source for the formation of nitric oxide in vascular endothelial cells, nerve cells and macrophages. NO plays a major role in the process of relaxation of vascular smooth muscle, which leads to a decrease in blood pressure and prevents the formation of blood clots. NO is of great importance for the normal functioning of the nervous and immune systems.
To date, the following effects of L-arginine have been experimentally and clinically proven:
One of the most effective stimulators of growth hormone production, allows you to maintain its concentration at the upper limits of the norm, which improves mood, makes a person more active, proactive and resilient. Many gerontologists explain the phenomenon of longevity by an increased level of growth hormone in centenarians.
· Increases the rate of recovery of damaged tissues — wounds, tendon sprains, bone fractures.
· Increases muscle and reduces body fat, effectively helping to lose weight.
Effectively enhances sperm production, used to treat infertility in men.
Plays an essential role in the process of memorizing new information.
It is a hepatoprotector — a protector that improves liver function.
Stimulates the activity of macrophages — cells that protect the body from the aggression of foreign bacteria.
DNA — deoxyribonucleic acid — a source of nucleotides for the synthesis of its own DNA in actively proliferating cells (epithelium of the gastrointestinal tract, blood cells, vascular endothelial cells):
Powerfully stimulates cellular regeneration and regenerative processes, accelerates wound healing.
· It has a pronounced positive effect on the immune system, enhances phagocytosis and local immunity, thereby dramatically increasing the body’s resistance and immunity to infections.
Restores and enhances the adaptive capacity of organs, tissues and the human body as a whole.
Of course, each person in the cell has his own, unique DNA, its uniqueness is ensured by the sequence of nucleotides, and if something, just a little bit — a couple of nucleotides, is not enough, or due to a lack of one of the vitamins, some element will be assembled incorrectly — all the work for nothing! The defective cell will be destroyed! For this, the body has a special supervisory department of the immune system.
Here, in order for the recovery to be as efficient as possible, to slow down the aging process, LongaDNA was created. LongaDNA is food for the endothelium.